Optimizing the Optimizer: Language Models Discover Faster Molecular Relaxation

Artem Tsypin, Vladimir Deshchenya, Kuzma Khrabrov, Denis Potapov, Maxim Radchenko, Artur Kadurin, Michael G. Medvedev

Optimizing the Optimizer: Language Models Discover Faster Molecular Relaxation: 4 upvotes on Hugging Face Daily Papers, #20 of 47 papers on 2026-10-06. Day-by-day upvote history.

Geometry optimization is a major cost in many quantum-chemical workflows: each optimization step requires one force evaluation, and at the density-functional level that evaluation dominates the wall time. Research in this area has produced a broad range of optimization methods, and we ask whether a language model can improve on the best of them through autoresearch. An agent rewrites the optimizer itself to minimize force-call counts, restrained by two admission gates that reject premature stopping and improvements that do not generalize to unseen molecules. Starting from Sella, the fastest open-source optimizer available, the search produces AutoSella, a family of two optimizers. Both of them deliver consistent force-call reductions relative to Sella across held-out molecular benchmarks and potentials not used during the search. Most notably, at the r2SCAN-3c DFT level, the best variant requires only 40.2--77.2% of Sella's force calls while achieving the same energy reduction, even though agent used no DFT gradients.

Paper page on Hugging Face · arXiv

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